Natural Product Chemistry

Prof. Dr. Thomas Lindel

Natural Products - Tools of Life

Publications and Patents

"N-Oxide Route to the Marine Natural Product Cyanogramide D", D. M. Sarnes, V. Struck, P. G. Jones, T. Lindel, Synthesis 2024, 56, 408-417.

"Synthesis of the indeno[1,2-b]indole core of janthitrem B", M. Fresia, A. Dierks, P. G. Jones, T. Lindel, Org. Biomol. Chem. 2023, 21, 9065-9069.

"Multigram, chromatography-free synthesis of the flavonol morin", G. Gurzadyan, S. Mende, A. Schmid, T. Lindel, Org. Proc. Res. Dev. 2023, 27, 890-898.

"Azido and desamino analogs of the marine natural product oroidin", L. Anders, T. Lindel, Z. Naturforsch. 2023, 78b, 181-187.

"Biomimetic synthesis of cyanogramides B and C", D. M. Sarnes, P. Jones, T. Lindel, Org. Lett. 2022, 24, 2479-2481.

"Aza-BODIPY route to ageladine A", C. Tolle, M. Fresia, T. Lindel, Org. Lett. 2022, 24, 1308-1312.

"Synthesis of pyranocyclopentaindolines representing the western sections of janthitrem B, JBIR-137, and shearinine G", M. Fresia, T. Lindel, Eur. J. Org. Chem. 2022, e202101451.

"Incorporation of 4J-HMBC and NOE data into computer-assisted structure elucidation with WebCocon", M. Köck, T. Lindel, J. Junker, Molecules 2021, 26, 4846.

"Di- and trifluorinated 2-azidobenzimidazole derivatives: synthesis, photooxygenation, and 19F NMR prediction", N. E. Kanitz, M. Fresia, P. G. Jones, T. Lindel, Eur. J. Org. Chem. 2021, 33572-33577.

"Synthesis of (–)-dihydroraputindole D by enantioselective benzoylation of a 1,3-diol intermediate", M. Fresia, M. Kock, T. Lindel, Chem. Eur. J. 2020, 26, 12733-12737.

"Insights into the Cnx1E-catalyzed MPT-AMP hydrolysis", T. W. Hercher, J. Krausze, S. Hoffmeister, D. Zwerschke, T. Lindel, W. Blankenfeldt, R. R. Mendel, T. Kruse, Biosci. Rep. 2020, 40, BSR20191806.

"Synthesis of raputimonoindoles A-C and congeners", M. Kock, M. Fresia, P. G. Jones, T. Lindel, Eur. J. Org. Chem. 2019, 4061-4065.

"Synthesis of morin and morin derivatives", T. Lindel, S. Mende, PCT Int. Appl. 2019, WO 2019101353 A1 20190531; Eur. Pat. Appl. 2019, EP 3486240 A1 20190522

"Synthesis of the polyketide section of seragamide A and related cyclodepsipeptides via Negishi cross coupling", J. H. Lang, T. Lindel, Beilstein J. Org. Chem. 2019, 15, 577-583.

"Tackling the spiro tetracyclic skeleton of cyanogramide: incorporation of a hydantoin moiety", M. Monecke, T. Lindel, Org. Lett. 2018, 20, 7969-7972.

"Macrocyclic core of salarin C: synthesis and oxidation", J.-N. Schäckermann, T. Lindel, Org. Lett. 2018, 20, 6948-6951.

"Synthesis of eunicellane-type bicycles embedding a 1,3-cyclohexadiene moiety", A. Frichert, P. G. Jones, T. Lindel, Beilstein J. Org. Chem. 2018, 14, 2461-2467.

"Diastereoselective total synthesis of raputindole A", M. Kock, T. Lindel, Org. Lett. 2018, 20, 5444-5447.

"Total synthesis and absolute configuration of raputindole A", M. Kock, P. G. Jones, T. Lindel, Org. Lett. 2017, 19, 6296-6299.

"Oxidation of the meroterpenoid (–)-terreumol C from the mushroom Tricholoma terreum: discovery of cytotoxic analogs", A. Frichert, P. G. Jones, M. Brönstrup, T. Lindel, J. Nat. Prod. 2017, 80, 2652-2658.

"Total synthesis of the marine natural product hemiasterlin via organocatalyzed hydrazination", J. H. Lang, P. G. Jones, T. Lindel, Chem. Eur. J. 2017, 23, 12714-12717.

"Aminopyrazine Pathway to the Moco Metabolite Dephospho Form A", A. Klewe, T. Kruse, T. Lindel, Chem. Eur. J. 2017, 23, 11230-11233.

"Synthesis and photooxidation of the trisubstituted oxazole fragment of the marine natural product salarin C", J.-N. Schäckermann, T. Lindel, Org. Lett. 2017, 19, 2306-2309.

"Chemistry and biology of the pyrrole-imidazole alkaloids", T. Lindel, Alkaloids Chem. Biol. 2017, 77, 117-219.

"Photoreactivity of monofluorinated 2-azidobenzimidazoles towards carboxylic acids", N. E. Kanitz, T. Lindel, Z. Naturforsch. 2016, 71b, 1287-1300; Widmung Prof. Dr. Gerhard Erker.

"Enantioselektive Totalsynthese der Terreumole A und C aus dem Pilz Tricholoma terreum", A. Frichert, P. G. Jones, T. Lindel, Angew. Chem. 2016, 128, 2969-2972; Angew. Chem. Int. Ed. 2016, 55, 2916-2919; Widmung Prof. Dr. Henning Hopf.

"Study on the synthesis of the cyclopenta[f]indole core of raputindole A", N. Marsch, M. Kock, T. Lindel, Beilstein J. Org. Chem. 2016, 12, 334-342.

"Synthesis of hydroxypyrrolone carboxamides employing Selectfluor", T.-C. Allmann, R.-P. Moldovan, P. G. Jones, T. Lindel, Chem. Eur. J. 2016, 22, 111-115.

"Total synthesis of the marine natural product parazoanthin F by copper-mediated C-N coupling", J. Wefer, T. Lindel, Eur. J. Org. Chem. 2015, 6370-6381.

"SmI2-mediated dimerization of indol-6-ylbutenones and synthesis of the myxobacterial natural product indiacen B", N. Marsch, P. G. Jones, T. Lindel, Beilstein J. Org. Chem. 2015, 11, 1700-1706.

"Enantioselective synthesis and photoreactivity of a diazirinyl-substituted (R)-beta-phenylalanine", J.-N. Schäckermann, T. Lindel, Z. Naturforsch. 2014, 69b, 1088-1096; Widmung Prof. Dr. Hubert Schmidbaur.

"Synthesis, stability, and photoreactivity of diazirinyl-substituted N-heterocycles based on indole, benzimidazole, and imidazole", B. Raimer, T. Wartmann, P. G. Jones, T. Lindel, Eur. J. Org. Chem. 2014, 5509-5520.

"Quantum chemical calculation of 19F NMR chemical shifts of trifluoromethyl diazirine photoproducts and precursors", B. Raimer, P. G. Jones, T. Lindel, J. Fluorine Chem. 2014, 166, 8-14.

"Water-compatible photoarylation of amino acids and peptides", A. Sudakow, U. Papke, T. Lindel, Chem. Eur. J. 2014, 20, 10223-10226.

"Synthesis and cytotoxicity of a diazirine-based photopsammaplin", F. Hentschel, B. Raimer, G. Kelter, H.-H. Fiebig, F. Sasse, T. Lindel, Eur. J. Org. Chem. 2014, 2120-2127.

"Total synthesis and cytotoxicity of the marine natural product malevamide D and a photoreactive analog", W. Telle, G. Kelter, H.-H. Fiebig, P. G. Jones, T. Lindel, Beilstein J. Org. Chem. 2014, 10, 316-322.

"Doubly Prenylated Tryptamines: Cytotoxicity, Antimicrobial Activity and Cyclisation to the Marine Natural Product Flustramine A", S. K. Adla, F. Sasse, G. Kelter, H.-H. Fiebig, T. Lindel, Org. Biomol. Chem. 2013, 11, 6119-6130.

"Synthesis of a 30-membered macrocycle incorporating two ruthenium sandwich complexes", A. Schmid, K. Polborn, T. Lindel, Z. Naturforsch. 2013, 68b, 707-713; Widmung Prof. Dr. Heinrich Nöth.

"Photoactivation of (p-methoxyphenyl)(trifluoromethyl)diazirine in the presence of phenolic reaction partners", B. Raimer, T. Lindel, Chem. Eur. J. 2013, 19, 6551-6555.

"Pinacol approach to the eunicellane skeleton", M. Al Batal, P. G. Jones, T. Lindel, Eur. J. Org. Chem. 2013, 2533-2536.

"L-Phototryptophan", T. Wartmann, T. Lindel, Eur. J. Org. Chem. 2013, 1649-1652; dem Andenken an Prof. Dr. Richard Neidlein gewidmet.

"Cubitane: a rare diterpenoid skeleton", J. Wefer, K. Simon, T. Lindel, Phytochem. Rev. 2013, 12, 95-105.

"Enantioselektive Totalsynthese des Diterpens (+)-Cubiten", K. Simon, J. Wefer, E. Schöttner, T. Lindel, Angew. Chem. 2012, 124, 11047-11050; Angew. Chem. Int. Ed. 2012, 51, 10889-10892.

"Synthesis and biological activity of fluorescent psammaplin derivatives", F. Hentschel, F. Sasse, T. Lindel, Org. Biomol. Chem. 2012, 7120-7133.

"Identification of superoxide production by Arabidopsis thaliana aldehyde oxidases AAO1 and AAO3", M. Zarepour, K. Simon, M. Wilch, U. Nieländer, T. Koshiba, M. Seo, T. Lindel, F. Bittner, Plant. Mol. Biol. 2012, 80, 659-671.

"Microwave-assisted fluorination of 2-acylpyrroles: synthesis of fluorohymenidin", B. Troegel, T. Lindel, Org. Lett. 2012, 14, 468-471.

"Photochemical arylation of Brønsted acids with 2-azidobenzimidazole", A. Sudakow, P. G. Jones, T. Lindel, Eur. J. Org. Chem. 2012, 681-684.

"Synthesis and cytotoxicity of ring C-functionalized derivatives of the marine natural product (–)-dibromophakellstatin", R.-P. Moldovan, M. Zöllinger, P. G. Jones, G. Kelter, H.-H. Fiebig, T. Lindel, Eur. J. Org. Chem. 2012, 685-698; Widmung Prof. Dr. William Fenical.

"Indole prenylation in alkaloid synthesis", T. Lindel, N. Marsch, S. K. Adla, Top. Curr. Chem. 2012, 309, 67-130; Widmung Prof. Dr. Gerhard Bringmann.

"Total synthesis of rhodiolosides A and D and of sachalinols A-C", K. Simon, P. G. Jones, T. Lindel, Eur. J. Org. Chem. 2011, 1493-1503; Widmung Prof. Dr. Henning Hopf.

"Study on the absolute configuration of (–)-palau'amine", T. Lindel, D. E. N. Jacquot, M. Zöllinger, R. B. Kinnel, S. McHugh, M. Köck, Tetrahedron Lett. 2010, 51, 6353-6355.

"Assembly of the bisimidazolylpropene core of nagelamides C and S by double Grignard reaction", N. Jacobi, T. Lindel, Eur. J. Org. Chem. 2010, 5415-5425; Widmung Prof. Dr. Richard Neidlein.

"Study on the NBS-induced rearrangement of 2-tert.-prenyltryptamines", S. K. Adla, G. Golz, P. G. Jones, T. Lindel, Synthesis 2010, 2161-2170.

"Enantiospecific synthesis of the cubitane skeleton", E. Schöttner, P. G. Jones, T. Lindel, Org. Lett. 2010, 12, 784-787.

"Synthesis of oximinotyrosine-derived marine natural products", F. Hentschel, T. Lindel, Synthesis 2010, 181-204.

"Improved conversion of dihydrooroidin to oroidin and ugibohlin", R.-P. Moldovan, T. Lindel, Z. Naturforsch. 2009, 64b, 1612-1616; Widmung Prof. Dr. Hubert Schmidbaur.

"Enantiospecific synthesis of a novel rearranged eunicellane diterpenoid by SmI2-mediated cyclization", E. Schöttner, P. G. Jones, T. Lindel, Synthesis 2009, 3941-3956.

"Skeleton diversity by cyclopropanation of tricyclic acylenamines", M. Zöllinger, P. Mayer, T. Lindel, Z. Naturforsch. 2009, 64b, 617-623; Widmung Prof. Dr. Gerhard Maas.

"Synthesis and stereochemistry of (–)-rosiridol and (–)-rosiridin", E. Schöttner, K. Simon, M. Friedel, P. G. Jones, T. Lindel, Tetrahedron Lett. 2008, 49, 5580-5582.

"Chemistry unprotected", M. Köck, T. Lindel, Angew. Chem. 2007, 119, 5362-5365; Angew. Chem. Int. Ed. 2007, 46, 5268-5271.

"Synthesis of 4-substituted 2-aminoimidazoles from a stable iminophosphorane building block", C. Pöverlein, N. Jacobi, P. Mayer, T. Lindel, Synthesis 2007, 3620-3626.

"Enantioselective total synthesis of (–)-dibromophakellstatin", M. Zöllinger, P. Mayer, T. Lindel, Synlett 2007, 2756-2758.

"Quantum chemical calculations on the electronic circular dichroism of (–)-dibromophakellin and (–)-dibromophakellstatin", I. Atodiresei, M. Zöllinger, T. Lindel, J. Fleischhauer, G. Raabe, Chirality 2007, 19, 542-549.

"Total synthesis of flustramine C via dimethylallyl rearrangement", T. Lindel, L. Bräuchle, G. Golz, P. Böhrer, Org. Lett., 2007, 9, 283-286.

 "Antitumor activity of the marine natural product dibromophakellstatin in vitro", M. Zöllinger, G. Kelter, H.-H. Fiebig, T. Lindel, Bioorg. Med. Chem. Lett. 2007, 17, 346-349.

"Total synthesis of dibromophakellstatin via three-component imidazolidinone anellation", M. Zöllinger, P. Mayer, T. Lindel, J. Org. Chem. 2006, 71, 9431-9439.

"Diels-Alder reactions of oroidin and model compounds", C. Pöverlein, G. Breckle, T. Lindel, Org. Lett. 2006, 8, 819-821.

"Challenge palau'amine: current standings", D. E. N. Jacquot, T. Lindel, Curr. Org. Chem. 2005, 9, 1551-1565.

"Oxidative cyclization of a seco-cladiellane diterpenoid", M. Friedel, G. Golz, P. Mayer, T. Lindel, Tetrahedron Lett. 2005, 46, 1623-1626.

"Total synthesis of the marine natural product rac-dibromophakellstatin", D. E. N. Jacquot, M. Zöllinger, T. Lindel, Angew. Chem. 2005, 117, 2336-2338; Angew. Chem. Int. Ed. 2005, 44, 2295-2298.

"Isolation, structure elucidation and synthesis of curcutetraol", T. Mülhaupt, H. Kaspar, S. Otto, C. Reichert, G. Bringmann, T. Lindel, Eur. J. Org. Chem. 2005, 334-341.

"Decomposition of oroidin in DMSO/TFA", T. Lindel, G. Breckle, M. Hochgürtel, C. Volk, A. Grube, M. Köck, Tetrahedron Lett. 2004, 45, 8149-8152.

"Synthesis of L-aminohomohistidine (L-Ahh)", M. Friedel, T. Lindel, Tetrahedron Lett. 2004, 45, 2779-2781.

"Modular synthesis of ruthenium-labeled diaryl ether peptoids", A. Schmid, T. Lindel, Angew. Chem. 2004, 116, 1607-1609, Angew. Chem. Int. Ed. 2004, 43, 1581-1583.

"Chiroptical analysis of marine sponge alkaloids sharing the pyrrolopyrazinone core", D. E. N. Jacquot, P. Mayer, T. Lindel, Chem. Eur. J. 2004, 10, 1141-1148.

"Synthesis of the pyrrole-imidazole alkaloids", H. Hoffmann, T. Lindel, Synthesis 2003, 1753-1783.

"5-Hydroxytryptophan: antioxidant principle of the sun-loving sponge Hymeniacidon heliophila", N. Lysek, R. Kinscherf, R. Claus, T. Lindel, Z. Naturforsch. 2003, 58c, 568-572.

 "One-step preparation of [RuCp*(eta6-arene)]+ sandwich complexes", A. Schmid, H. Piotrowski, T. Lindel, Eur. J. Inorg. Chem. 2003, 2255-2263.

"Synthesis of the pyrrole-imidazole alkaloid sventrin from the marine sponge Agelas sventres", G. Breckle, K. Polborn, T. Lindel, Z. Naturforsch. 2003, 58b, 451-456.

"Synthesis of ruthenium-labelled tripeptoids with alternating amide and diaryl ether bonds", D. Leone-Stumpf, T. Lindel, Eur. J. Org. Chem. 2003, 1853-1858.

"Total synthesis of the spirotryprostatins", T. Lindel in Organic Synthesis Highlights V (Hrsg.: H.-G. Schmalz, T. Wirth), WILEY-VCH, Weinheim, 2003, S. 360-367.

"Sanglifehrin A: an immunosuppressive natural product from Malawi", T. Lindel in Organic Synthesis Highlights V (Hrsg.: H.-G. Schmalz, T. Wirth), WILEY-VCH, Weinheim, 2003, S. 350-359.

"Polyene cyclization to adociasulfate", T. Lindel, C. Hopmann in Organic Synthesis Highlights V (Hrsg.: H.-G. Schmalz, T. Wirth), WILEY-VCH, Weinheim, 2003, S. 342-349.

"Alkyne metathesis in natural product synthesis", T. Lindel in Organic Synthesis Highlights V (Hrsg.: H.-G. Schmalz, T. Wirth), WILEY-VCH, Weinheim, 2003, S. 27-35.

"Isolation and structure elucidation of deformylflustrabromine from the North Sea bryozoan Flustra foliacea", N. Lysek, E. Rachor, T. Lindel, Z. Naturforsch. 2002, 57c, 1056-1061.

"Synthesis of the dipyrrolopyrazinone core of dibromophakellstatin and related marine alkaloids", D. E. N. Jacquot, H. Hoffmann, K. Polborn, T. Lindel, Tetrahedron Lett. 2002, 43, 3699-3702.

"Validation of structural proposals by substructure analysis and 13C NMR chemical shift prediction", J. Meiler, E. Sanli, J. Junker, R. Meusinger, T. Lindel, M. Will, W. Maier, M. Köck, J. Chem. Inf. Comput. Sci. 2002, 42, 241-248.

"Synthesis and chromatography [CpRu]+-complexed bastadin precursors", D. Leone-Stumpf, T. Lindel, Chem. Eur. J. 2001, 7, 3961-3965.

"Total syntheses of the marine natural product eleutherobin", T. Lindel in Organic Synthesis Highlights IV (Hrsg.: H.-G. Schmalz), WILEY-VCH, Weinheim, 2000, S. 268-274.

 "Synthesis of the marine natural product Nalpha-(4-bromopyrrolyl-2-carbonyl)-L-homoarginine, a putative biogenetic precursor of the pyrrole-imidazole alkaloids", T. Lindel, M. Hochgürtel, M. Assmann, M. Köck, J. Nat. Prod. 2000, 63, 1566-1569.

"Structure-activity relationship of the inhibition of fish feeding by sponge-derived and synthetic pyrrole-imidazole alkaloids", T. Lindel, H. Hoffmann, M. Hochgürtel, J. R. Pawlik, J. Chem. Ecol. 2000, 26, 1477-1496.

"Synthesis of the marine natural product oroidin and its Z-isomer", T. Lindel, M. Hochgürtel, J. Org. Chem. 2000, 65, 2806-2809.

"Chemistry of marine pyrrole-imidazole alkaloids", T. Lindel, H. Hoffmann, M. Hochgürtel in New Perspectives in Bioorganic Chemistry (Hrsg.: U. Diederichsen, T. K. Lindhorst, B. Westermann, L. A. Wessjohann), WILEY-VCH, Weinheim, 1999, S. 8-17.

"Impact of the 1H,15N-HMBC experiment on the constitutional analysis of alkaloids", M. Köck, J. Junker, T. Lindel, Org. Lett. 1999, 1, 2041-2044.

"Computer-assisted constitutional assignment of large molecules: COCON analysis of ascomycin and palytoxin", J. Junker, W. Maier, T. Lindel, M. Köck, Org. Lett. 1999, 1, 737-740.

"A COCON analysis of proton-poor heterocycles - application of carbon chemical shift predictions for the evaluation of structural proposals", M. Köck, J. Junker, W. Maier, M. Will, T. Lindel, Eur. J. Org. Chem. 1999, 579-586.

"2D NMR-guided constitutional analysis of organic compounds employing the computer program COCON", T. Lindel, J. Junker, M. Köck, Eur. J. Org. Chem., 1999, 573-577.

"The alkyne pathway to keramadine from the marine sponge Agelas sp.", T. Lindel, M. Hochgürtel, Tetrahedron Lett. 1998, 39, 2541-2544.

"Eleutherobin, a novel cytotoxic agent that induces tubulin polymerization, is similar to paclitaxel (Taxol)", B. H. Long, J. M. Carboni, A. J. Wasserman, L. A. Cornell, A. M. Casazza, P. R. Jensen, T. Lindel, W. Fenical, C. R. Fairchild, Cancer Res. 1998, 58, 1111-1115.

"Von (D)-Arabinose zum Marinen Naturstoff Eleutherobin", T. Lindel, Angew. Chem. 1998, 110, 806-808; Angew. Chem. Int. Ed. 1998, 37, 774-776.

"Synthesis of dispacamide from the marine sponge Agelas dispar", T. Lindel, H. Hoffmann, Tetrahedron Lett. 1997, 38, 8935-8938.

"Eleutherobin, a new cytotoxin that mimics paclitaxel (Taxol) by stabilizing microtubules", T. Lindel, P. R. Jensen, W. Fenical, B. H. Long, A. M. Casazza, J. Carboni, C. R. Fairchild, J. Am. Chem. Soc. 1997, 119, 8744-8745.

"COCON: from NMR correlation data to molecular constitutions", T. Lindel, J. Junker, M. Köck, J. Mol. Model. 1997, 3, 364-368.

"Synthesis of rac-midpacamide and the spiro-cyclization of its precursor", T. Lindel, H. Hoffmann, Liebigs Ann./Recueil 1997, 1525-1528.

"Chemical defense of the Caribbean sponge Agelas clathrodes (Schmidt)", B. Chanas, J. R. Pawlik, T. Lindel, W. Fenical, J. Exp. Mar. Biol. Ecol. 1996, 208, 185-196.

"Eleutherobin and analogs thereof", W. Fenical, P. R. Jensen, T. Lindel, US-Patent 5,473,057, 1995, Chem. Abstr. 1996, 124, P194297z.

"Lagunapyrones A-C: cytotoxic acetogenins of a new skeletal class from a marine sediment bacterium", T. Lindel, P. R. Jensen, W. Fenical, Tetrahedron Lett. 1996, 37, 1327-1330.

 "Synthesis and biomimetic rearrangement of a chiral diterpene diepoxide", T. Lindel, B. Franck, Tetrahedron Lett. 1995, 36, 9465-9468.

 

Prof. Dr. Thomas Lindel

Curriculum vitae


TU Braunschweig
Institute of Organic Chemistry
Hagenring 30
38106 Braunschweig
Germany

phone int+49 531 391 7300
fax int+49 531 391 7744
th.lindel tu-bs.de



Karin Dietz
int+49 531 391 5256
k.dietz tu-bs.de